Ben Smit CV

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B J Smit

Publications     Published proceedings of international congresses
Paper / Poster presentations at national congresses
Other paper / poster presentations     Chapters in books
Books    Additional    Research projects

PERSONAL DETAILS

First Names:	Berend Jakobus
Surname:	Smit
Date of birth:	16 November 1935
Nationality:	South African
Marital status:	Married
Languages:	English and Afrikaans

PUBLICATIONS

SMIT BJ, VAN DER MERWE A. Hydroxyurea and cisplatinum as radiosensitizers in advanced carcinoma of the cervix. Specialist Medicine 1993;15:8-20.

SMIT BJ, VERNIMMEN F. Drug management of radiation side effects. Specialist Medicine 1993;15:40-49.

SMIT BJ, VAN DER MERWE A. Preliminary Results of a Prospective Randomized Controlled Clinical Trial With Hydroxyurea and Cisplatinum as Radiosensitizers in Advanced Carcinoma of the Cervix. Radiation Oncology Investigations 1993; 1: 117-125.

SMIT BJ. Technical Note: Design features of the indwelling intrauterine tube for high dose rate intracavitary therapy for carcinoma of the cervix and some hints on its optimal use. The British Journal of Radiology 1993; 66: 1042-1043.

BöHM L, SMIT BJ. Editorial: Cancer therapy at the Faure cyclotron - a case for the continuation of high-tech medicine. South African Medical Journal 1995;85:116-117.

STANNARD C, VERNIMMEN F, JONES D, WILSON J, VAN WIJK L, BRENNAN S, SCHREUDER N, SYMONS J, LEVIN V, MILLS E, ALBERTS A, WERNER D, SMIT B, SCHMITT G. Neutron Therapy Program at the National Accelerator Centre, South Africa: Preliminary Results. Radiation Oncology Investigations 1995;2:245-255.

SMIT BJ, KILEY JE, SCHMITT G. Radiation oncology needs in South Africa. Hospital Supplies August 1995;3-8.

ALBRECHT CF, KRUGER PB, SMIT BJ, FREESTONE M, GOUWS L, MILLER R, VAN JAARSVELD PP. The pharmacokinetic behaviour of hypoxoside taken orally by patients with lung cancer in a phase I trial. South African Medical Journal 1995;85:861-865.

SMIT BJ, ALBRECHT CF, LIEBENBERG RW, KRUGER PB, FREESTONE M, GOUWS L, THERON E, BOUIC PJD, ETSEBETH S, VAN JAARSVELD PP. A Phase I Clinical Trial of Hypoxoside as an Oral Prodrug for Cancer Therapy - Absence of Toxicity. South African Medical Journal 1995;85:865-870.

SMIT BJ. Brachyradiotherapy in clinical practice. Hospital Supplies June 1996; 3-14.

SMIT BJ. Editorial: `Translational research', the `linker laboratory' or a paradigm shift in cancer care? South African Medical Journal 1996;86:388.

STANNARD CE, VERNIMMEN FJ, JONES DTL, VAN WIJK AL, BRENNAN SM, VISSER AM, JOHNSON CA, WILSON JAG, MURRAY EA, LEVIN CV, MILLS EED, ALBERTS A, WERNER ID, SMIT BJ, SCHMITT G. The neutron therapy clinical programme at the National Accelerator Centre (NAC). Results of fast neutron therapy. Bulletin de Cancer/Radiotherapie 1996;83:87-92.

SMIT BJ, BECK L, ROTH SL. Gynäkologische Tumoren: Zervixkarzinom. in Onkologie systematisch: Diagnostik und interdisziplinäre Therapie maligner Tumoren. UNI-MED Verlag, International Medical Publishers, Germany 1999.

SMIT BJ. Brachytherapy in the Management of carcinoma of the cervix. Specialist medicine, September 1998.

SMIT BJ. Radiation related prognostic factors in radiation oncology. Distinguished Expert Series: Eur. J. Gynaec. Oncol., 7-12, 2000.

Michie J, Janssens D, Cilliers J, Smit BJ, Böhm L. Assessment of electroporation by flow cytometry. Cytometry, 41:96-101, 2000.

Vernimmen FJ, Harris JK, Wilson JA, Melvill R, Smit BJ, Slabbert JP. Stereotactic proton beam therapy of skull base meningiomas. Int. J. Radiation Oncology Biol. Phys., 49(1) : 99-105, 2001.

PUBLISHED PROCEEDINGS OF INTERNATIONAL CONGRESSES

SMIT BJ. Radiotherapy as primary therapy for endometrial carcinoma. Proceedings of the Joint Course of the European Institute of Oncology, Milan, and the Hungarian Society of Gynecologic Oncologists, Budapest. Nogyogyaszati Onkologia, Hungarian Journal of Gynecologic Oncology 1996;2:147-149.

SMIT BJ. Radiation therapy versus surgery for early stage carcinoma of the cervix. Proceedings of the Joint Course of the European Institute of Oncology, Milan, and the Hungarian Society of Gynecologic Oncologists, Budapest. Nogyogyaszati Onkologia, Hungarian Journal of Gynecologic Oncology 1996;2:167-170.

SMIT BJ, DU TOIT GC. The management of advanced and recurrent carcinoma of the cervix. Proceedings of the Joint Course of the European Institute of Oncology, Milan, and the Hungarian Society of Gynecologic Oncologists, Budapest. Nogyogyaszati Onkologia, Hungarian Journal of Gynecologic Oncology 1996;2:180-182.

PAPER / POSTER PRESENTATIONS AT INTERNATIONAL CONGRESSES

(Not published as congress proceedings)SMIT BJ. Particle therapy (neutrons and protons) at the National Accelerator Centre (NAC) at Faure. 16th African Health Sciences Congress. Nairobi, Kenia, 1995.

SMIT BJ. Comparison of the indwelling intra-uterine tube and Foley's bulb with tandem ring and tandem ovoid systems. 8th International Brachytherapy Conference and Gammamed Users Meeting. Linz, Austria, 1995.

JOHNSON CA, STANNARD CE, VERNIMMEN F, WERNER ID, SMIT B. The Faure Experience of Neutron Irradiation for Irresectable Malignant Melanoma. 4th World Conference on Melanoma. Sydney, Australia, 1997.

SMIT BJ, GROENEWALD WA. Radiosurgery and Constraints in Dose-Volume Relationships. 11th International Meeting of Gynaecological Oncology, Budapest, Hungary, 1999.

PAPER / POSTER PRESENTATIONS AT NATIONAL CONGRESSES

SMIT BJ. Experience with Afterloading Techniques in Management of Cervical Cancer. 5th Gynaecological Oncology Congress. Waterfront, Cape Town, 1994.

ALBERTS A, SMIT BJ, BRUINS K, MOUTON R. Samarium EDTMP in Carcinoma of the Prostate (Hormone Escaped Metastatic CA {HEPC}). Urological Oncology Symposium. UCT Waterfront Campus, Cape Town, 1994.

SMIT BJ, ALBRECHT CF, LIEBENBERG RW, FREESTONE M, GOUWS L, THERON E, BOUIC PJD. Phase I Clinical Trial of Hypoxoside as an Oral Prodrug for Cancer Therapy. Annual Conference of the Pharmacology Society, UCT. Sea Point, 1994.

STANNARD C, VERNIMMEN F, VAN WIJK L, BRENNAN S, VISSER AM, JOHNSON C, WILSON J, LEVIN V, MILLS E, ALBERTS A, WERNER D, SMIT B, SCHMITT G, KRANOLD D, MURRAY E, GUDGEON A, BENTAL N, ABRATT R, KILEY J, VAN DER MERWE A, KEULER R, GOEDHALS L, KRAWITZ H, DONDE B, BAIRSTON S, FRIEDIGER D, DREYER A, REDDI V, MORGAN M. The National Neutron Therapy Programme Update. Combined Congress of the South African Society of Medical Oncologists and the South African Society of Radiation Oncologists. Thaba Nchu Sun, Bloemfontein, 1995.

JOHNSON CA, STANNARD CE, VERNIMMEN F, MILLS E, WERNER ID, SMIT B. The Faure Experience of Neutron Irradiation for Irresectable Malignant Melanoma. Combined Congress of the South African Society of Medical Oncologists and the South African Society of Radiation Oncologists. Thaba Nchu Sun, Bloemfontein, 1995.

VERNIMMEN F, WILSON J, STANNARD C, SCHREUDER N, SYMONS J, JONES D, HOUGH J, SMIT B. Proton Therapy at the National Accelerator Centre : An Overview. Combined Congress of the South African Society of Medical Oncologists and the South African Society of Radiation Oncologists. Thaba Nchu Sun, Bloemfontein, 1995.

DU TOIT GC, SMIT BJ. Curative Radiotherapy in Stage III Cervical Carcinoma: A Travesty in Terms? Combined Congress of the South African Society of Medical Oncologists and the South African Society of Radiation Oncologists. Thaba Nchu Sun, Bloemfontein, 1995.

SMIT BJ, VAN DER MERWE AP, VAN DER MERWE EJ, MICHIE J, CLOETE J. Preliminary report on a Hyperthermia project for carcinoma of the uterine cervix. Combined Congress of the South African Society of Medical Oncologists and the South African Society of Radiation Oncologists. Thaba Nchu Sun, Bloemfontein, 1995.

SMIT BJ, VAN DER MERWE AP, MOUTON R. A critical appraisal of the use of "ovoids", "rings" and "line sources" in Brachytherapy for carcinoma of the cervix. Combined Congress of the South African Society of Medical Oncologists and the South African Society of Radiation Oncologists. Thaba Nchu Sun, Bloemfontein, 1995.

SMIT BJ, SIEBRITS GA. A new treatment radiotherapeutic technique for carcinoma of the penis. SASMO/SASRO Congress, Holiday Inn Crown Plaza, Durban, 1997.

SMIT BJ, VAN DER MERWE AP, VERNIMMEN F, GROENEWALD W, VISSER A, APFFELSTAED J, VAN DER MERWE A, MAIN M, STEWARD C, COETZEE J. Photodynamic Therapy with Foscan. SASMO/SASRO Congress, Sea Point, Cape Town, 1998.

SMIT BJ, GROENEWALD WA. Dose-Volume Relationships in Radiosurgery. First Kansa Oncology School, National Accelerator Centre, Faure, 1999.

SMIT BJ, GROENEWALD WA. Constraints in Dose-Volume Relationships in Radiosurgery. Combined Meeting on Hadron Therapy, Sea Point, Cape Town, 1999.

SMIT BJ. Dose Volume Relationships in Radiosurgery. SASMO/SASRO Congress, CSIR, Pretoria, 17-19 March 2000.

SMIT BJ. Management of Radiotherapy Complications in Gynaecologic Oncology. 8th Meeting of the Gynaecologic Oncology Society, SA Society of Gynaecologic Oncology Conference, Protea Hotel Kruger Gate, Mpumalanga, 3 May - 6 May 2001.

OTHER PAPER / POSTER PRESENTATIONS

SMIT BJ. Samarium in Pain Control. A 1 day Symposium to celebrate 10 years of the Oncology Nursing Society of the Western Cape. Groote Schuur Hospital, Cape Town, 1994.

SMIT BJ. 153-SM as Palliatiewe Middel vir Beenpyn as gevolg van Metastatiese Prostaatkarsinoom. 38ste Akademiese Jaardag, Fakulteit Geneeskunde, Universiteit van Stellenbosch. Tygerberg, 1994.

SMIT BJ. Management of head and neck tumours - neutron and proton treatments. National Hospice Congress. Stellenbosch, 1995.

ALBRECHT C, THERON E, KRUGER P, VAN JAARSVELD P, VAN DER MERWE M, SMIT B, BOUIC P, FREESTONE F, WENTELER G, LIEBENBERG R. Hypoxoside - A novel Phytomedicinal, non-toxic, pro-drug for the treatment of certain cancers. Second National Conference of the Cancer Association of South Africa and the University of Cape Town, Langebaan, 1997.

SMIT BJ, GROENEWALD, WA. Dose-Volume in radiosurgery: a novel way to prescribe. First National CANSA Oncology School. Convenor: BJ Smit, National Accelerator Centre, Faure, 1999.

SMIT BJ. Invited speaker: Budapest, May 1999 and chairman of session.
SMIT BJ. Chairman: Session on Brachytherapy at Brachytherapy Meeting, Cyprus, May 1999.

SMIT BJ. Radiochirurgie: Nuwe toepassings in radioterapie vir breinletsels. Spiespunt Voordrag, 44ste Akademiese Jaardag, Universiteit van Stellenbosch, Tygerberg Kampus, 23-24 Augustus 2000.

SMIT, BJ. Nuwe ontwikkeling in kankerterapie. Openbare Lesing oor Kanker, Universiteit van Stellenbosch, Tygerberg Kampus, 30 Augustus 2000.

SMIT, BJ. Radiochirurgie: Geskiedenis, Tegniese Aspekte, Bestaande geriewe in die RSA, Indikasies. VPO lesing gehou deur die Onkologie Eenheid van Durbanville in samewerking met Durbanville Medi-Clinic, Fairways Restaurant, Welgemoed Golfklub, 13 September 2000.

SMIT BJ. Radiosurgery and constraints in Dose Volume Relationships. Guest speaker at Middlesex Hospital and Royal Marsden Hospital on new development in Radiosurgery. London, UK, 18 May 2000.

CHAPTERS IN BOOKS

SMIT BJ, SCHMITT G. High-Dose-Rate-(HDR-) Afterloading-therapie in Kombination mit perkutaner Therapie beim inoperablen Zervixkarzinom. In: Roth SL, Böttcher HD, (eds). Gynäkologische Strahlentherapie. Enke Verlag F, Stuttgart, 1993: 38-44.

Smit BJ, Beck L, Roth SL: Gynäkologische Tumoren: Zervixkarzinom. In Schmidt, G. Onkologie systematische: Diagnostik und interdisziplinäre Therapie maligner Tumoren. UNI-MED Verlag, International Medical Publishers, Germany 1999: 121-125.

BOOKS

BREUER H, SMIT BJ. Proton Therapy and Radiosurgery. Springer-Verlag, Germany, 2000.

ADDITIONAL

Member, Techinical Advisory Panel, Foundation for Research Development.
Ex-Secretary, S.A. Society of Radiotherapists.
Ex-Chairman, S.A. Society of Radiotherapists.
Alternative Head Radiotherapist, National Accelerator Centre.
Examiner for Radiotherapy, S.A. College of Medicine.
Reviewer for the S.A. Medical Journal.
Appointed on Editorial Board of Radiation Oncology Investigations. (An International Journal).
Member of the Evaluation Panel for Radiotherapy and Radiobiology, Medical Research Council.
Co-promotor, Doctoral Thesis, Dr WA Groenewald, Radiotherapy Department, Faculty of Medicine, Univeristy of Stellenbosch, 1979.
Co-winner, Mer National Prize for the best article in "Geneeskunde" 1986.
Certificate of Merit for contributions to High Dose Rate Brachytherapy 1992.
Special Mention, section "Oncology Abstracts", of outstanding article in its field, in Clinical Digest Series (Prospects for Proton Therapy in Ca. Cervix, Int. J. Rad. Oncol. Biol. Phys. 1992).
Recipient of the Dr. Kurt Sauerwein Medal by the European International Brachytherapy Group (Sponsor: Isotopen-Technik Dr. Sauerwein GMBH, Haan, Germany) 1993, for outstanding work in the field of radiation therapy.
Associate of the Faculty of Radiology of The College of Medicine of South Africa.
Visiting Professor to the Oncology Group, Department of Obstetrics and Gynaecology, University of the Witwatersrand, 1993.
Member of the Advisory Panel on Medical Biophysics, Medical Research Council.
Co-recipient of the Alex Mortimer Memorial Award for research on Samarium153.
Founder member of the Aristoteles Society, Greece.
Recipient of Certificate of Appreciation by the Cancer Association of South Africa, for research in combating cancer, 1995.
Member of the Physics Work Group of the Curriculum Committee for M.B., Ch.B. I, 1996.
Vice Chairman of the Forum for Radiation Protection, since 1996.
Member of Radiation Research Society, since 1996.
Member of the Committee for Radiation Oncology at the College of Medicine of South Africa, 1999.
Member of an interviewing panel for the Clinical Research/Hospital Manager post at the National Accelerator Centre at Faure, 1999.
Project Leader of Audit Team on Radiotherapy facilities in Tunesia. Requested by the IAEA (International Atomic Energy Agency), ), 14 - 18 December 1998.
Member of SASMO (South African Society of Medical Oncologists).
Member of the panel of experts with regard to medical and dental professional conduct matters (Gynaecology, Prostate, Radiosurgery), Medical and Dental Professional Board, Health Professions Council of South Africa, 1999.
National Cancer Week 1999 - Vredendal, Western Cape. Talks on Prostate Cancer. CANSA.
Radio Namakwaland, Vredendal. Radio discussion on Prostate and Testis Cancer, organised by CANSA Rondebosch, 26 August 1999.
Chairman of the "Temozolomide Launch", Two Oceans Aquarium, Waterfront, Cape Town. Sponsored by Schering-Plough (Pty) Ltd., 12 October 1999.
Speaker: Prostate and Testis Cancer. Organised by CANSA. Wellington Town Hall, 27 October 1999.
Tygerberg Management Team, 1999.
Member: Panel of experts with regard to Medical and Dental Professional Conduct Matters. HPCSA, 2000.
Chairman of Session. SASMO/SASRO Congress, CSIR, Pretoria, 17-19 March 2000.
Investigators' Meeting: Astra Zeneca, for ZD1839 ('Iressa'), Geneve, Switzerland, 19-21 June 2000.
Member: American Association for the Advancement of Science.
Colleges of Medicine of South Africa: Awarded the Fellowship by Peer Review of the College of Radiation Oncologists (CMSA), 2000.

RESEARCH PROJECTS

Dosimetric studies of carcinoma of the cervix.
Proton therapy development.
Electro-porosity and electro-chemotherapy.
Simultaneous hyperthermia and radiation for carcinoma of the cervix.
Intra-operative radiotherapy.
Samarium153 in: (a) late, and (b) early metastatic carcinoma of the prostate in co-operation with principal, Albert Alberts. (First National co-operative study outside protons/neutrons).
Predictive assays and tumour cell kinetics with flow cytometry.
Photodynamic Therapy (PDT) for early oral carcinomas.
PDT for recurrent oral carcinomas.
Various "contract research" projects with chemotherapy.
Co-operative project with The Strahlenklinik in Offenbach, Germany (Proff Zambouglou, Balthas).
Co-developer with Dermatology and the Centre of Electronic Services, University of Stellenbosch, for the development of the PDT light-source, August 1999.
Investigation into the dose-volume effects of radio-surgery.
Revised: November 2000

Books